Update on Glucocorticoid Induced Osteoporosis

Mechanism of Glucocorticoid-Induced Osteoporosis: An Update

Synthetic oral steroids were initially developed in the 1940-1950’s. Although their use was initially limited by their high cost, as they became more affordable and began to be used for treatment of a wide variety of conditions, side effects associated with their use became much more prevalent. In fact, glucocorticoid-induced osteoporosis is now the most common secondary cause of osteoporosis. ...

Glucocorticoid-induced Osteoporosis

Glucocorticoid induced osteoporosis.

Glucocorticoid therapy is the most common cause of secondary osteoporosis and the leading iatrogenic cause of the disease. Often, the presenting manifestation is fracture, which occurs in 30% to 50% of patients receiving long-term glucocorticoid therapy. Glucocorticoid-induced osteoporosis predominantly affects regions of the skeleton that have abundant cancellous bone such as lumbar spine and ...

Glucocorticoid-induced osteoporosis

Corticosteroid-induced osteoporosis is the most common form of secondary osteoporosis and the first cause in young people. Bone loss and increased rate of fractures occur early after the initiation of corticosteroid therapy, and are then related to dosage and treatment duration. The increase in fracture risk is not fully assessed by bone mineral density measurements, as it is also related to al...

Glucocorticoid-induced osteoporosis.

Glucocorticoid-induced osteoporosis is one of the most important side-effects of glucocorticoid use, leading to an increased fracture risk. In this review, recent advances in the understanding of the mechanisms of glucocorticoid-induced osteoporosis are summarised. Methods to identify persons at risk for fractures are discussed, as well as the new ACR recommendations for the prevention and trea...